Microscopy Imaging Center

PhD Defense L. van Os

Lisette van Os, student at the PhD program Cutting Edge Microscopy (CEM) under the supervision of Prof. Dr. Olivier Guenat, will give her thesis defense on April 27, 2023.

Title: Immune cell migration during infection in organs-on-chip

Abstract: Organ-on-chip models aim at replacing traditional animal experiments in the research and drug development pipeline. Current organ-on-chip models can replicate the functional unit of an organ, but often do not include an immune component. In this project, an organ-on-chip model of lung infection was developed, to study immune cell migration during the acute infection phase. Live microscopy was carried out to follow the migration pattern of immune cells under different (inflammatory) conditions. Immune cell migration during lung inflammation could be visualized in real time.