Microscopy Imaging Center


Congratulations to successful PhD Defense Daniëlle Verschoor

On February 10, 2023 Daniëlle Verschoor, student of the Cutting Edge Microscopy (CEM) program under the supervision of Prof. Stephan von Gunten, has successfully defended her PhD thesis with the title: “Granulocytes, fragile but resistant. Unraveling the treatment resistance of granulocytes.”

Her PhD project focused on the treatment resistant of inflammatory granulocyte, both neutrophils and eosinophils. Freshly isolated human peripheral granulocytes were stimulated with pro-inflammatory cytokines as GM-CSF and/or IL-5 followed by treatments as intravenous immunoglobulins, anti-siglec-7/9 or glucocorticoids to investigate their cell survival or death and to investigate possible mechanism involved in this response. This all to unravel the mechanism responsible for their resistance to these treatments.

Fundamentals of wide field microscopy

The MIC Training "Fundamentals of wide field microscopy" will take place on May 09 - 11, 2023. Content of the course will be: Basics of wide field microscopy. Basics of fluorescence. Filters and light sources. Digital cameras and digital imaging. Basics of image visualisation and processing, deconvolution and denoising. 
On request, PhD students of the Cutting-Edge Microscopy program can obtain 1.5 ECTS upon presenting the learning outcome in the context of their project at a presentation event.

Registration closes on May 2, 2023.

Detailed information and the registration form are to be found on ILIAS.

Demonstration Events

The InCell Analyser (INCA) high-throughput microscope at the Vetsuisse Faculty has to be replaced soon. To learn about the performance of instruments on the market demonstration events will be held for the Molecular Device (Nano/Micro) instrument on March 27-30 and for the Cytation 5 and 10 instruments on April 18-19, 2023. Please contact Prof. Kässmeyer, Dr. Kerry Woods or Dr. Helena Röss if you are interested in joining these demonstration events.

MIC Workshop: Performance Test in Light Microscopy

In collaboration with the Friedrich Miescher Institute for Biomedical Research in Basel, the MIC will offer the course “Performance Test in Light Microscopy”. It will take place on April 26-27, 2023. The course will present some basic performance tests to diagnose issues and benchmark performance of light microscopes. Please find all further information on the flyer below.

In case you are interested, please send your application to: yury.belyaev@mic.unibe.ch

Application deadline: March 10, 2023

CEM Study Trip 2023

In February 2023, a study trip took the PhD students of the PhD program Cutting Edge Microscopy (CEM) to Freiburg i.B., Germany. Here, the students visited the Life Imaging Center (LIC) of the University of Freiburg. The institute is headed by Dr. Roland Nitschke, who warmly welcomed the students and led them through the 2-day program together with his team. A relaxing tour through the beautiful city center of Freiburg i.B. completed the program. Read more about the study trip of the CEM PhD students to Freiburg in the pdf file linked below.

Advanced Imaging Course - UniFR

The Microscopy Imaging Center (MIC) collaborates with the Bioimage Core Facility of the Department of Biology and the Section of Medicine of the University of Fribourg. The course Advanced Imaging - Super-resolution fluorescence microscopy is open for PhD students of the Cutting Edge Microscopy specialization program.

Fluorescence microscopy has become the preferred imaging tool for biological systems due to its capability to visualize specifically the target biomolecules under conditions compatible with life, like room temperature, liquid environment and irradiation with visible light. Fluorescence microscopy also provides very high sensitivity down to the detection of single molecules. As drawback, as it happens with any a far-field optical technique, the spatial resolution is limited by the wavelength of light to a few hundreds of nanometres (the so-called diffraction limit). Remarkably, in the mid 2000s, a series of imaging methods using fluorescence readout were developed that deliver images with resolution beyond the diffraction limit. These methods, called super-resolution fluorescence microscopy or far-field fluorescence nanoscopy and whose pioneers were awarded with the Nobel Prize in Chemistry in 2014, have revolutionized biological imaging and continued to be developed until the present day.

Detailed information are to be found on ILIAS here. KSL: 482916

PhD Defense M. Golomingi

Murielle Koni-Kepo Golomingi student at the PhD program Cutting Edge Microscopy (CEM) under the supervision of Prof. Dr. Verena Schröder, will give her PhD Defense on March 15, 2023 at 14.00 at the ARTORG Center for Biomedical Engineering Research.
Title: “Interactions between the complement system and blood coagulation: a potential role of complement components and activation during haemostasis"

Haemostasis is a crucial process by which the body stops bleeding. It is achieved by the formation of a platelet plug, which is strengthened by the formation of a fibrin mech through the coagulation cascade. In case of pathological clotting, for instance in arterial thrombosis, the interactions of the complement system and the coagulation cascades is known to aggravate the development of the pathology. Whether those interactions play a relevant role during non-pathological haemostasis is however not yet completely understood. The aim of this study was to investigate the potential role of complement components and activation during haemostasis.

It is time to navigate your career maze!

The Life Science Zürich Young Scientist Network (LSZYSN) invites you to the Zurich Life Science Day, on the 7th of February 2023 at Irchel Campus. This is a day-long career fair and networking event with the most talented life scientists and companies. 

The LSZYSN is a non-profit organization composed of PhD students and Post-Doctoral researchers from ETH and University Zurich. Our goal is to connect life scientists with their career opportunities beyond academia.

Over the last 12 years, the ZLSD has grown into the largest job fair for life scientists in Switzerland, hosting more than 700 participants and 100 company representatives on site at the Irchel Campus of the University of Zurich. Due to the Covid-19 situation we went virtual the last 2 years and hosted over 2000 participants from all over the globe, who connected with company representatives over informal 1-1 meetings, and numerous chatting options. However, ZLSD is back on campus and you get to do all networking in person. 

Register now!

Muldimodal Imaging

On February 2, 2023 the AGORA Cancer Research Center invites you to the workshop titled "Multimodal Imaging in life sciences and cancer research". Keynote speaker is Ralph Weissleder, Harvard/ MGH, USA. More details and registration on the pdf below. 

SNSF Scientific Image Competition

Get your cameras and give Swiss research a face!
The SNSF Scientific Image Competition encourages researchers working in Switzerland to present their works to the public and the media. Photographs, images and videos will be rated in terms of their aesthetic quality and their ability to inspire and amaze, to convey or illustrate knowledge, to tell a human story or to let us discover a new universe.
Submission deadline is January 31, 2022. Learn mor here.


First protocol for Monitoring the point spread function

MIC congratulates Dr. Yury Belyaev on his co-authorship in a new publication on the use of the point spread function for quality control of confocal microscopes. The paper can be downloaded here.

Benchtop High-Speed Confocal Microscope

Yury Belyaev (MIC) and Fabian Blank (DBMR) invite you to this demonstration event organized  in collaboration with Witec AG. More details and registration on the flyer below.



Congratulation to successful PhD Defense

On September 20, 2022 Raphaela Seeger, student of the PhD program Cutting Edge Microscopy (CEM) has successfully defended her PhD thesis entitled "Investigating synaptic vesicle exocytosis by structural studies of rat synaptosomes". 

During this project synapses were isolated and treated with an exocytosis triggering solution prior to vitrification by plunge freezing to achieve a temporal resolution and investigate the morphofunctional changes in the synapses' architecture via cryo-electron tomography. In parallel, tomograms of synapses with a mutated exocytosis-relevant-molecule (SNAP25) from collaborators (University of Copenhagen) were evaluated and compared with the results of the time-resolved exocytosis events. Further, a deep-learning software to automate the segmentation of synaptic vesicles was created in a collaboration with another PhD student from the Zuber lab.

Swiss Microscopy Core Facility Day 2022

The 10th Swiss Microscopy Core Facility Day took place this year on September 15 - 16, 2022 and was organised by Pascal Lorentz from the Department of Biomedicine at the University of Basel. To celebrate the 10th anniversary, this normally one-day event, was organised as a two-day retreat in Engelberg. About 60 members of Swiss microscopy facilities and representative of different microscopy companies convened for informative presentations and intensive discussion on questions related to various aspects of microscopy faculty operation.  The focus of this year’s meeting was the well-being of the facility staff.

On the first day, the leading microscopy companies shared their experiences in supporting good working atmosphere among employees. Additionally, Christel Genoud from the University of Lausanne presented the results of a facility survey on the working conditions of microscopy facility employees. On the second day, after Zeiss’ presentation of Zeiss on the latest developments in artificial intelligence (AI) software and Evident’s brief overview of corporate wellbeing issues, the participants were able to participate in variouse workshops. All workshops were led by professional coaches and gave an insight into modern psychological methods tackling questions of mental health, self-reflection and conflict management.

As usual, the meeting offered many opportunities for networking and exchange of experiences during its social program. Yury Belyaev represented the Microscopy Imaging Center (MIC) at this meeting. Next year the Swiss Core Facility Day will take place at ETH Zurich organised by ScopeM.

MIC at "Nacht der Forschung 2022"

The Nacht der Forschung at the University of Bern took place on September 10, 2022. The room of the microscopy imaging center (MIC), UniS A015, was decorated with various posters about the MIC and about microscopy at our University. Activities included "Microscopy for everyone" on 6 teaching microscopes and an excursion into virtual reality, which beamed the guest into the brain of a mouse or into a fish head. In room A-126 of UniS, microscopists offered lectures on exciting topics. A total of around 30 helpers from the MIC committee, friends of the MIC and students of the PhD program Cutting Edge Microscopy headed by Fabian Blank, Ruslan Hlushchuk and Ruth Lyck were on duty in 3 shifts from 4:00 p.m. to midnight. Further activities of MIC committee members were offered in the University’s main building by Stefan Tschanz and Benoît Zuber on behalf of the Institute of Anatomy. All activities were eagerly attended. Interested conversations and happy children's faces testified to the success of our offers. The MIC team says a big "THANK YOU" to all the helpers, without whom the MIC activities would not have been possible.


Scanning System VS200 and All-in-One Microscope APX100

This workshop, organized in collaboration with Yury Belyaev (MIC) and Fabian Blank (DBMR), will take place on October 5, 2022 at the Department for BioMedical Research, Bern. For further details please see the flyer below. 

Entry-level position at the Imaging Core Facility (IMCF) 

The Imaging Core Facility (IMCF) of the Biozentrum of the University of Basel is offering a position to a young scientist to enter the field of modern high-end light microscopy. More details see here.

Translational molecular imaging: Using a mass spectrometer as a microscope

The Department for BioMedical Research (DBMR) at the University of Bern is hosting Prof. Dr. Ron M.A. Heeren from the Molecular Imaging Institute, Maastricht University at the DBMR Research Conference.

The conference is taking place on October 31, 2022 at the Langhans Auditorium. More information here.

PhD midterm presentation by MD Adrian Madarasz

On December 16, 2022 at 2.00 pm. Title:  “Circulation and clearance of cerebrospinal and brain interstitial fluid in murine models of hemorrhagic stroke". Location: Theodor Kocher Institute, University of Bern.

MD Adrian Madarasz is enrolled in the PhD program Cutting Edge Microscopy and conducts his thesis under the supervision of Dr. Steven Proulx at the Theodor Kocher Institute

Abstract of his presentation: Hemorrhagic stroke is associated with high disability and mortality rates. Most therapeutic approaches lack broad agreement, especially for the reduction of brain edema. By inducing disease models for intracerebral and subarachnoid hemorrhage in mice followed by in vivo imaging with near-infrared tracers and labels, we assess changes in brain interstitial and cerebrospinal fluid circulation and investigate potential efflux pathways for fluids and cells from the subarachnoid space.


Meet the MIC at the "Nacht der Forschung"

The MIC team invites the public to inspect fascinating specimen through a microscope, to see posters about the MIC and some microscopy examples done at the University of Bern and to enjoy 3D images in virtual reality in room A015. In addition, MIC experts will held presentations  at 5.00, 6.00, 8.00, 9.00 and 10.00 pm in room A-126.

Workshop on Bioimage Processing with Python

From July 11 to 15, 2022, the 1st MIC Workshop on Bioimage Processing with Python, led by MIC team member Dr. Guillaume Witz, took place in the Bernese Oberland. A mix of eight participants from the University of Bern, three from European universities and one from a private company learned how to develop Python-based bioimage processing workflows using cutting edge tools like cellpose, napari etc. Participants also had the opportunity to work on their own projects and to discuss them with Guillaume Witz and with each other. It was a great experience to see how concepts and tools just taught were applied live to those projects, and how participants made massive progress in such a short time! During breaks and evening time the beautiful park of Sherlock Holme's favourite hotel in Meiringen was a wonderful stage for many more informal discussions on science, microscopy, biology etc. made especially interesting by the participants' diverse backgrounds. Finally, participants also enjoyed the many hiking and excursion possibilities available in Meiringen to recover from an intensive learning program. Inspired by this success, MIC will organize the 2ndMIC Workshop on Bioimage Processing in 2023. Stay tuned and visit our website for announcements!

CryoEM symposium - UHZ, Center for Micoscopy and Image Analysis

The UZH Center for Microscopy and Image Analysis invites to a mini-Symposium dedicated to the inauguration of the Titan Krios G3i on Monday, 3rd October 2022 at the Irchel Campus, University of Zürich. The Krios series represents cryo-transmission electron microscopes (TEMs) with atomic resolution. Therefore, this symposium could be helpful for you if you are dealing with TEM in your research projects.

Please have a look at the program and register here.

Congratulations to an important research achievement!

Congratulations to Dr. Coralie Dessauges and the research group of Professor Olivier Pertz, Institute of Cell Biology, Faculty of Science, University of Bern, on the publication of their project "Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics" in the EMBOpress journal Molecular Systems Biology in June 2022, downloadable at https://doi.org/10.15252/msb.202110670. In this work, Coralie and co-workers built circuits consisting of an optogenetic actuator to activate MAPK signaling with blue light and an ERK biosensor to measure single-cell ERK dynamics. The inducing light pulse is automatically provided by the microscope, allowing the simultaneous study of dynamic ERK responses in thousands of cells. In summary, this project improves our understanding on the MAPK signaling interactome.  





CEM Summer School 2022

On June 30th and July 1, 2022, the annual summer school of the PhD program Cutting Edge Microscopy (CEM) took place at the Hotel Appenberg in Zäziwil, Switzerland. On the first day, the CEM PhD students presented their scientific projects and specific microscopic applications. Advice on the implementation of microscopy into the projects was provided by the MIC microscopy specialists Fabian Blank and Yury Belyaev, the MIC bioimaging specialist Guillaume Witz and the CEM PhD program co-directors Benoît Zuber and Steven Proulx. Furthermore, a discussion on the next activities of the CEM PhD program took place and Javier Pareja and Adrian Madarasz were elected as CEM student representatives from August 2022 to July 2023. On the second day, the external trainer Michael Berndonner carried out a very intensive training course in scientific presentation techniques. Moderation skills were also included in this course as an important topic for scientific conferences. The coordinator of the CEM PhD program, Ruth Lyck, also attended the CEM summer school and took care of all administrative issues. The beautiful landscape, the pleasant accommodation and the Appenberg games activity contributed to a perfect learning atmosphere.

Enabling imaging across scales

The First EMBL Imaging Centre Symposium ‘’Enabling imaging across scales’’ took place on May 31, 2022 at EMBL Heidelberg, Germany. At this meeting, Dr. Yury Belyaev represented the MIC and here reports about it.

21st International European Light Microscopy Initiative Meeting (ELMI)

The 21st International European Light Microscopy Initiative Meeting (ELMI) took place on June 7-10, 2022 in Turku, Finland. At this meeting, Dr. Yury Belyaev represented the MIC and here reports about it.

CEM Study Trip

In May 2022, a study trip took the PhD students of the PhD program Cutting Edge Microscopy to Strasbourg, France. Here, the students visited the Institute de génétique et biologie moléculaire et cellulaire (IGBMC). A relaxing tour through the beautiful center of Strasbourg completed the program. Read more about the workshops at the IGBMC on the pdf file below.

ZEISS Workshop online or in Basel

A Workshop dedicated to Tissue Clearing is jointly organized by The Imaging Core Facility (IMCF) of the Biocenter of the University of Basel and Zeiss on July 11 to 13, 2022
You will get the chance to explore this technology in different lectures in Basel or online. Specialists for ECI Clearing, Cubic Clearing and Smart Clearing will share their experiences. In the second part we will host a hands-on workshop, where you can carry out a selected clearing technique yourself. Further information here.

COMULIS training school "Imaging Across Scales"

29 August - 2 September 2022, Bern, Switzerland

The Microscopy Imaging Center and the Institute of Anatomy are organising a COMULIS training school ‘’Imaging across the scales’’ on 29 August – 2 September 2022 in Bern, Switzerland.  This is a 5-days in-presence course with 16 participants. The talks and hands-on sessions will cover uCT-EM workflows. The course main topics are: uAngioCT, uCT and EM sample preparation, multimodal imaging, and image processing. Registstration here.

Mica microscope workshop at the Institute of Pathology

22nd -23rd June, 09:00-18:00 CET 

It is our pleasure to invite you to book your personal demonstration of Mica - the world's first Microhub – hosted by the University of Bern at the Institute of Pathology. Discover true simultaneous 4-color widefield, confocal resolution and AI-supported analysis united in a sample-protecting incubator. All with a single push of a button!

Mica is a whole new way to do microscopy. Here’s why…

  • Access for all
    Automatic selection and optimization of imaging settings simplifies your experiment set-up and increases reproducibility
  • No constraints
    Visualize 4 colors simultaneously in widefield and then switch to confocal without ever moving your sample. Select the right modality in real time
  • Radically simplified workflows
    Intelligent automation and AI-supported analysis enables greater efficiency and a faster track to publication

Contact us to book a time for your live demonstration and have your questions answered. 

Where: University of Bern, Institut für Pathologie, L570, Murtenstrasse 31, 3008 Bern
If you are not available during this time, please write an E-Mail.

First meeting of the Swiss BioImage Analyst's Society

June 22, 2022

Do you analyse images of biological samples? Do you provide such analysis as a service in an imaging facilty or a lab?
If yes, register at the first meeting of the Swiss BioImage Analyst's Society for an informal day of exchange.

Swiss TriM Scope and Ultra Microscope User Meeting

Welcome to the Swiss User Meeting taking place on June 28, 2022. For program and registration please see flyer below.

Open position  as Analyst / Microscopist

The Center for Microscopy and Image Analysis at the University of Zurich offers a 4 year position. Further details see here.

11 - 15 Jul 2022: MIC Workshop on Bioimage Processing

If you want to get started using the Python eco-system for your bioimaging projects this intensive one-week workshop is the right thing for you. In addition to course time, you will also have some time to work on your own projects, just getting started or continuing an existing one, and will be able to discuss them with other participants and the instructor. PhD students of the GCB profit from a reduced price. More details on the pdf below, registration here.

Whole day live demo at DBMR Bern

A Revolutionary Approach to Detect, Characterize & Screen
Confocal+ Widefield + Multimode Reading= Stunning Images+ Analysis

Join us for an overview of BioTek's new, next generation Cytation instrument, the Cytation C10 Confocal Imaging Reader.
We' ll highlight workflows to obtain phenotypic and quantitative data across its broad application range . Registration here.

Artificial intelligence methods applied to intravital microscopy of the immune system

This hyprid workshop will cover theoretical and practical aspects regarding the application of new A.I. -based methods for the analysis
of migration and interaction of immune cells captured by 4D intravital imaging. Basic knowledge in imaging is recommended.

More information and registration here.

LS2 Prestige Webinar

MIC committee member Benoit Zuber, as part of the LS2 Biophysics section, invites you to the upcoming LS2 Prestige Webinar.
Topic: “CryoEM structures of amyloid filaments from human brain” 
When: 30th March 2022, 16:00 – 17:00 (CET)
Please register here.

Join the Cutting Edge Microscopy PhD program

Interested in becoming a world-class expert in biological imaging?
The CEM PhD program currently has a few vacancies. If you are a PhD student of the GCB and you apply advanced microscopy techniques in your PHD thesis, we are looking for you. Please find more details on the flyer below and do not hesitate to contact us.

Midterm presentation

Irene Spera, student of the PhD program Cutting Edge Microscopy (CEM), will give her midterm presentation on March 9, 2022 at 11:00 online via zoom. Title: "Factors regulating the exchange of cerebrospinal fluid and interstitial fluid of the brain".

Our project investigates the perineural outflow pathways of cerebrospinal fluid (CSF) at the cribriform plate and focused on the elucidation of anatomical connections between the subarachnoid space (SAS) and the lymphatics at the exiting nerve routes. Furthermore, we want to define the anatomical spaces of the CSF flow on the brain surface and elucidate the relationship between CSF and the interstitial fluid (ISF) of the brain. To address these aims, we made use of transgenic reporter mice, fluorescence microscopy, and through skull near-infrared (NIR) in vivo imaging.

Please request acess to this online event via e-mail to Rahel Eyer. 

Join the Correlative Microscopy Symposium 

March 13 - 16, 2022

The Organization Committee and the ZEISS Microscopy Team are delighted to invite you to the 6th Joint Meeting Workshop and Symposium “From 3D Light to 3D Electron Microscopy” taking place from March 13th to 16th 2022 in cooperation with the EMBL in Heidelberg, the VIB in Ghent and the Francis Crick Institute in London.
Many prominent scientists will share their groundbreaking work on correlative microscopy in 3D and volume EM. You can also look forward to practical workshops on

  • correlative workflows
  • volume EM methods
  • sample preparation methods

and on a panel discussion of the international networking happening to promote these techniques.
This meeting will inspire you and open up the possibilities for forming new collaborative efforts to use these powerful imaging techniques to better understand the nano-world inside cells and tissues. 
Please register here.

DCI Symposium 2022

The Dubochet Centre for Imaging (DCI) Symposium 2022 will take place in Lausanne and in Geneva June 8 to 10. More details and registration here.

Image analysis expert

The Friedrich Miescher Institute für Biomedical Research (FMI), Basel, is looking for an image analysis expert.. Please submit your application by February 25, 2022.  For more details see the Job add below.

SNSF Scientific Image Competition

​​​The SNSF Scientific Image Competition encourages researchers working in Switzerland to present their works to the public and the media. Photographs, images and videos will be rated in terms of their aesthetic quality and their ability to inspire and amaze, to convey or illustrate knowledge, to tell a human story or to let us discover a new universe. Submission deadline January 31, 2022. More information here.

PhD Defense

Federico Saltarin student ot the PhD program Cutting Edge Microscopy (CEM), will give his PhD defense on December 10, 2021 at 10.30  online via Zoom.
Title: “Investigations on the extravasation of melanoma cells across the blood brain barrier”.
Please request access to this online event via e-mail to Rahel Eyer.

Our project focuses on the investigation of the extravasation of melanoma cells across the blood brain barrier in the context of brain metastasis development.
To this aim, we addressed the impact of compromised endothelial junctions at the BBB on brain metastatic melanoma cell extravasation and we developed methods and tools for the investigation of melanoma brain metastasis formation on multi-scale level.

MIC Symposium 2021

Finally, after a missing year 2020 due to covid pandemic, the traditional MIC Symposium took place in UniS on November 19, 2021. The topic of this year was 3D electron microscopy.  The scientific committee represented by Wanda Kukulski, Michael Stoffel, Benoît Zuber (University of Bern) and Dimitri Vanhecke (University of Fribourg), prepared an interesting program, which attracted more than 110 participants. More details see here.


LS2 Intersection Microscopy 

The LS2 Intersection Microscopy together with the Swiss Society for Optics and Microscopy (SSOM) was founded in February 2019. During the past years, microscopy techniques as well as image analysis capabilities have developed at incredible pace. Today, microscopy based research is becoming increasingly important in all fields of life sciences. The LS2  microscopy intersection aims for a better and intensified knowledge transfer between the microscopy community and life scientists in Switzerland and thus intends to promote the faster introduction of new and cutting-edge microscopy techniques in Switzerland. Also, high-end microscopy techniques should become even better known as well as the core facilities providing them.

Apply for the LSmembership here and select "Microscopy" in the online application form.

PhD Defense

Martin Liptay student ot the PhD program Cutting Edge Microscopy (CEM), will give his PhD defense on October 1, 2021 at 15:00  online via Zoom.
Title: “Replication fork remodeling and PARP inhibitor resistance in Brca1/2-mutated mouse mammary tumors”.
Please request access to this online event via e-mail to Rahel Eyer.

Poly (ADP-ribose) polymerase inhibitors (PARPi) are a class of targeted therapeutics that recently entered the clinic for the treatment of patients suffering from BRCA1/2-mutated breast and ovarian cancer. Unfortunately, similar to other anticancer therapeutics, their efficacy in tumor eradication is frequently limited by acquired drug resistance. By employing a variety of molecular biology and imaging techniques, we identified novel, non-canonical functions of DNA repair proteins H2AX and MDC1 in the metabolism of replication forks and in mediating PARPi response in BRCA1/2-deficient mammary tumors.

Zietschmann-Preuss-Award 2021

The 2021 Zietzschmann-Preuss Award presented by the World Association of Veterinary Anatomists goes to Christina Alexandra Kalenberg, Department of Clinical Veterinary Science, University of Bern, post-graduate student of MIC Board member Michael Stoffel. We congratulate her on this success!

DOI: 10.1111/ahe.12525

Communication training for students of the PhD program Cutting Edge Microscopy (CEM)

The communication training for CEM students took place on 6 and 8 September 2021 in Berne. During two interesting and varied days, the participants had the opportunity to work on impactful speaking techniques, exercices for voice warming and were able to improve their personal skills under instruction of  Michael Berndonner, external public speaking and communication trainer.

PhD Defense

Eleonora Lupi, student ot the PhD program Cutting Edge Microscopy (CEM), will give her PhD defense on September 29, 2021 at 15:30  online via Zoom.
Title: “Establishment of a zebrafish screening assay for the identification of compounds affecting proepicardial and epicardial formation”.
Please request access to this online event via e-mail to Rahel Eyer.

Description: the epicardium is the most external layer of the heart that has been demonstrated to have an important role during heart formation and regeneration. Despite the increasing interesting on this tissue, some mechanisms leading its formation remain still unknown. With this project we aimed to study the effect of epigenetic modulators on the proepicardial and epicardial formation in zebrafish model, to better understand the epigenetic role in this process. A drug screening was performed and zebrafish embryos were imaged using an Acquifer imaging machine. We were able to implement an automatic pipeline to quantify the number of the epicardial cells and determine the effect of the drugs on the epicardium.

PhD Defense

Alberto Mattei, student ot the PhD program Cutting Edge Microscopy (CEM), will give his PhD defense on September 1, 2021 at 10.00 am online via Zoom
Title: "Exploring Signaling Mechanisms regulating genetic and non-genetic Drug Resistance in Melanoma"
Please request access to this online event via e-mail to Rahel Eyer.

"Metastatic melanoma is a very aggressive type of cancer that in over 50% of cases carries a BRAFV600E mutation. The mutated BRAF drives aberrant MAPK-ERK pathway activation and tumor progression. Selective BRAFV600E inhibitors have been on the market since 2011, but drug resistance almost invariably develops and patient relapse in the clinic. We explored mechanisms that regulate genetic and non-genetic drug resistance in melanoma."

Congratulations to new publication!

Congratulations to Yury Belyaev, Federico Saltarin, Ruth Lyck and Paolo Favaro from University of Bern and their collaborators to their new publication on "Learning to Reconstruct Confocal Microscopy Stacks From Single Light Field Images" published in IEEE Transactions on Computational Imaging in July 2021, DOI.

Swiss Microscopy Core Facility Day 2021

Registration for the 2021 Swiss Microscopy Core Facility Day at the new Biozentrum in Basel is open.
Link to registration here.

LS2 Webinar Series

The LS2 Microscopy Intersection is happy to organise the LS2 Microscopy Webinar Series. One Tuesday each month, a speaker will share their exciting work on imaging methods and their applications in science or industry.

The next LS2 Microscopy Webinar will take place on the 20th July 2021 at 17:00 (~30min plus Q&A time). Register here.

ZEISS Microscopy Image Contest 2021 

We are thrilled to announce the ZEISS Microscopy Image Contest 2021. Do you take stunning microscopy images? Submit your best image now!  The contest is open to all microscopy enthusiasts and professionals in any application field. Images can be taken with any ZEISS microscope (light, X-ray or electron microscope). Deadline for entry is July 31, 2021.

All participants will receive a copy of the ZEISS Microscopy Calendar 2022. On top of that, the three winners will receive the following prizes:

  • 1st Prize: ZEISS Primostar 3
  • 2nd Prize: ZEISS Victory Pocket 10x25
  • 3rd Prize: ZEISS Terra 10x42

To submit your image and read all FAQs and rules, visit our contest web page

New position in microscopy at Wyss Center, Geneva


The position is conceived to focus on transversal activities among the different microscopes and image analysis systems with technical roles on maintenance, assistance and quality control of the microscopes and integration of image analysis pipelines. The person will also be involved in the run of Wyss Center driven research projects.

Deadline 23th of July, with possibility of extension.

Exciting publication of Professor Olivier Pertz

We congratulate MIC committee member Oliver Pertz and his team to their exciting new study “Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival” published in Developmental Cell in June 2021.

QUAREP-LiMi WG 10 Image Quality Talk from Alan C. Bovik

"On Picture Quality Prediction"

Alan Bovik is a faculty member in the Department of Electrical and Computer Engineering, the Wireless Networking and Communication Group (WNCG), and the Institute for Neuroscience. His research interests include digital television, digital photography, visual perception, social media, and image and video processing. To recieve the Zoom link to this talk, please contact Yury Belyaev.

15th EXCITE Zurich Summer School

Registration is now open for the 15th EXCITE Zurich Summer School on Biomedical Imaging that will take place in Zurich, Switzerland, from 6 - 17 September 2021. Application deadline: Monday, 3 May 2021 (Notification of acceptance: 1 June 2021).


PhD Defense

Coralie Dessauges, student ot the PhD program Cutting Edge Microscopy (CEM), will give her PhD defense on May 3, 2021, at 1.00 pm. Title: An optogenetic actuator/biosensor circuit for large scale interrogation of MAPK signaling dynamics
Please request access to this online event via e-mail to Rahel Eyer.

In this work, we developed a set of optogenetic circuits to activate the MAPK/ERK pathway with light from different levels of the MAPK network and measure the corresponding ERK activity with a high temporal resolution. Together with automated imaging and image-analysis pipelines, our systems enable us to image and stimulate ERK signaling in hundreds of cells in a highly automated and dynamic fashion. Taking advantage of this throughput, we conducted an RNAi perturbation screen to investigate the role of 50 proteins of the MAPK network in ERK signaling regulation.

PhD Defense

Nora Ruef, student ot the PhD program Cutting Edge Microscopy (CEM), will give her PhD defense on March 26, 2021, at 4.00 pm. Please request access to this online event via e-mail to Rahel Eyer.

"In this thesis we investigated the unique migration mode of submandibular salivary gland tissue resident memory CD8+ T cells and how memory CD8+ T cells perform homeostatic surveillance of a complex organ with mixed epithelial – connective tissue composition."

PhD Defense

Julia Bruggisser, student of he PhD program Cutting Edge Microscopy (CEM), will give her PhD defense on March 25, 2021, at 3.00 pm. Please request access to this online event via e-mail to Rahel Eyer.

Title: Clostridium Perfringens β-Toxin: Receptor Identification and Oligomer Structure

Self-evaluation of the Microscopy Imaging Center (MIC)

Please complete the survey of the MIC here until March 16, 2021. This survey is designed to evaluate the performance of the MIC with respect to teaching and services. Your participation will help to implement improvements exactly there where you requested them most

New instrument at ARTORG

02.02.2021 - The newly acquired EVOS M7000 microscope from Thermo Fisher is a widefield fluorescence microscope, suitable for.... continue reading

White Paper of QUAREP-LiMi is online

29.01.2021 – Read the White Paper «QUAREP-LiMi: A community-driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy» here.

Virtual Seminar Invitation - ImageXpress Pico

02.03.2020 - When size doesn't matter: meet ImageXpress Pico, the miniature but mighty microscope. Continue reading

DBMR Hyperion Imaging System

02.11.20 – New MIC Instruments

Location: INO-F608A
Type: Imaging mass cytometer
Site: UniBE-Insel Read more

DBMR Helios Mass Cytometer

07.10.20 – New MIC Instruments

Location: INO-F608A
Type: Mass Cytometer
Site: UniBE-Insel Read more

DBMR Hyperion Imaging System

05.10.20 – New MIC Instruments

Location: INO-F608A
Type: Imaging mass cytometer
Site: UniBE-Insel Read more

LHEP Keyence VHX-7000

05.10.20 – New MIC Instruments

Location: Gebäude der exakten Wissenschaften (ExWi)
Type: Widefield Microscope
Site: UniBE-ExWi Read more

IZB Nanolive 3D Cell Explorer

10.08.20 – New MIC Instruments

Location: Institute of Cell Biology, Baltzerstrasse 4, 3012 Bern
Type: Widefield Microscope
Site: UniBE-Muesmatt Read more

IRM ThermoFisher Phenom XL Scanning EM (Bob)

02.11.20 – New MIC Instruments

Location: Institute of Forensic Medicine, Bühlstrasse 20, 3012 Bern
Type: Electron Microscope
Site: UniBE-Muesmatt Read more